Antibiotics at birth and later antibiotic courses: effects on gut microbiota/Experiment 1
Curated date: 2021/12/03
Curator: Mmarin
Revision editor(s): WikiWorks, LGeistlinger, Fatima, Mmarin, ChiomaBlessing, OdigiriGreat
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Antimicrobial agent antibiotic,antibiotics,Antibiotika,Antibiotikum,antibiotique,antimicrobial,antimicrobial agents,microbicide,microbicides,Antimicrobial agent,antimicrobial agent
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- perinatal antibiotics
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants who received any perinatal antibiotics (all three perinatal groups combined)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 27
- Group 1 sample size Number of subjects in the case (exposed) group
- 73
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- NA
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Pielou Quantifies how equal the community is numerically
- unchanged
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Richness Number of species
- unchanged
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- unchanged
Signature 1
Source: table 2
Description: Composition of the gut microbiome in vaginally delivered infants (N = 100) exposed to perinatal antibiotics as compared with the control group after the first year of life.
Abundance in Group 1: increased abundance in perinatal antibiotics
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Clostridium | ||
| Escherichia coli | ||
| Faecalibacterium | ||
| Prevotella |
Revision editor(s): OdigiriGreat, ChiomaBlessing
Signature 2
Source: table 2
Description: Composition of the gut microbiome in vaginally delivered infants (N = 100) exposed to perinatal antibiotics as compared with the control group after the first year of life.
Abundance in Group 1: decreased abundance in perinatal antibiotics
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Bacteroidia |
Revision editor(s): OdigiriGreat, ChiomaBlessing
