Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-14
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Mood disorder affective disorders,episodic mood disorder,major mood disorders,mood disorder,mood disorders,Mood disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls (HCs)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Major depressive disorder (MDD)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants who suffer from depressive episodes from major depressive disorder (MDD)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 217
- Group 1 sample size Number of subjects in the case (exposed) group
- 165
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.5
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
- Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
- unchanged
Signature 1
Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-14
Source: Supplementary file: Figure. S4a.
Description: Discriminative OTUs observed in the pairwise comparisons between major depressive disorder (MDD) and healthy controls (HC).
Abundance in Group 1: increased abundance in Major depressive disorder (MDD)
Revision editor(s): Chinelsy, ChiomaBlessing
Signature 2
Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-14
Source: Supplementary file: Figure. S4a.
Description: Discriminative OTUs observed in the pairwise comparisons between major depressive disorder (MDD) and healthy controls (HC).
Abundance in Group 1: decreased abundance in Major depressive disorder (MDD)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides |
Revision editor(s): ChiomaBlessing
