Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression/Experiment 3

From BugSigDB


Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-14

Curated date: 2023/10/29

Curator: Chinelsy

Revision editor(s): Chinelsy, Rahila

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Mood disorder affective disorders,episodic mood disorder,major mood disorders,mood disorder,mood disorders,Mood disorder
Group 0 name Corresponds to the control (unexposed) group for case-control studies
bipolar disorder (BD)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Major depressive disorder (MDD)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Participants who suffer from depressive episodes from major depressive disorder (MDD)
Group 0 sample size Number of subjects in the control (unexposed) group
217
Group 1 sample size Number of subjects in the case (exposed) group
165
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 month

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2.5
Matched on Factors on which subjects have been matched on in a case-control study
age, body mass index


Signature 1

Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-14

Curated date: 2023/10/29

Curator: Chinelsy

Revision editor(s): Chinelsy, ChiomaBlessing

Source: Supplementary file: Figure. S4c.

Description: Discriminative OTUs observed in the pairwise comparisons between major depressive disorder (MDD) and bipolar disorder (BD).

Abundance in Group 1: increased abundance in Major depressive disorder (MDD)

NCBI Quality ControlLinks
Agathobacter rectalis
Anaerobutyricum hallii
Bacteroides
Bifidobacterium
Blautia
Eggerthella
Escherichia/Shigella sp.
Faecalibacterium
Peptostreptococcaceae
Streptococcus
Thomasclavelia
Prevotella sp.
Coprococcus sp.

Revision editor(s): Chinelsy, ChiomaBlessing

Signature 2

Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-14

Curated date: 2023/10/29

Curator: Chinelsy

Revision editor(s): Chinelsy, ChiomaBlessing

Source: Supplementary file: Figure. S4c.

Description: Discriminative OTUs observed in the pairwise comparisons between major depressive disorder (MDD) and bipolar disorder (BD).

Abundance in Group 1: decreased abundance in Major depressive disorder (MDD)

NCBI Quality ControlLinks
Anaerostipes
Bacteroides
Blautia
Butyricicoccus
Dialister
Enterococcus
Faecalibacterium
Lachnoclostridium
Phascolarctobacterium
Pseudomonas
Romboutsia
Streptococcus
Prevotella sp.

Revision editor(s): Chinelsy, ChiomaBlessing