Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Folakunmi on 2024-1-27

Curated date: 2023/10/30

Curator: Chinelsy

Revision editor(s): Chinelsy, Peace Sandy

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Postcholecystectomy syndrome Postcholecystectomy Syndrome,postcholecystectomy syndrome,Postcholecystectomy syndrome
Group 0 name Corresponds to the control (unexposed) group for case-control studies
healthy control (HC)
Group 1 name Corresponds to the case (exposed) group for case-control studies
post-cholecystectomy (PC)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Participants who have post-cholecystectomy (PC) syndrome are difficult to treat.
Group 0 sample size Number of subjects in the control (unexposed) group
20
Group 1 sample size Number of subjects in the case (exposed) group
31
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
3 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2


Signature 1

Reviewed Marked as Reviewed by Folakunmi on 2024-1-27

Curated date: 2023/10/30

Curator: Chinelsy

Revision editor(s): Chinelsy

Source: Fig. 1D

Description: Comparison of gut microbiota structure and abundance between post-cholecystectomy (PC) and healthy control (HC) groups. Logarithmic linear discriminant analysis scores identify the taxa with the greatest differences in abundance between the healthy control and post-cholecystectomy groups.

Abundance in Group 1: increased abundance in post-cholecystectomy (PC)

NCBI Quality ControlLinks
Bifidobacteriaceae
Bifidobacteriales
Actinomycetota
Clostridiaceae 1Clostridiaceae 1
Veillonellaceae
Selenomonadales
Negativicutes

Revision editor(s): Chinelsy