The gut microbiota and metabolite profiles are altered in patients with spinal cord injury/Experiment 1
From BugSigDB
Needs review
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- typically healthy control group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- spinal cord injury patient
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Spinal cord injury (SCI) is an insult to the spinal cord resulting in a change, either temporary or permanent, in the cord's normal motor, sensory, or autonomic function
- Group 0 sample size Number of subjects in the control (unexposed) group
- 10
- Group 1 sample size Number of subjects in the case (exposed) group
- 11
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- DNA-DNA Hybridization
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, Confounders controlled for: "gender" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.gender, Confounders controlled for: "injury duration" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.injury duration, Confounders controlled for: "injury site" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.injury site
Signature 1
Needs review
Source: Figure 3
Description: Alterations in the gut microbiota at the phylum and genus levels between the two groups.
Abundance in Group 1: increased abundance in spinal cord injury patient
| NCBI | Quality Control | Links |
|---|---|---|
| Synergistota | ||
| UBA1819UBA1819 | ||
| Eggerthella |
Revision editor(s): Omojokunoluwatomisin
Signature 2
Needs review
Curated date: 2024/03/12
Curator: Omojokunoluwatomisin
Revision editor(s): Omojokunoluwatomisin, Ayibatari
Source: Figure 3
Description: Alterations in the gut microbiota at the phylum and genus levels between the two groups.
Abundance in Group 1: decreased abundance in spinal cord injury patient
Revision editor(s): Omojokunoluwatomisin, Ayibatari
