Curcumin Regulates Gut Microbiota and Exerts a Neuroprotective Effect in the MPTP Model of Parkinson's Disease/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Curcumin (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione,C21,C21H20O6,COc1cc(ccc1O)\\\\C=C\\\\C(=O)CC(=O)\\\\C=C\\\\c1ccc(O)c(OC)c1,DC42,Diferuloylmethane,FLJ12894,InChI=1/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+,InChIKey=VFLDPWHFBUODDF-FCXRPNKRBF,IRA1,Kacha haldi,Natural yellow 3,TBL1XR1 wt Allele,TBLR1,Transducin (Beta)-Like 1 X-Linked Receptor 1 wt Allele,Transducin (Beta)-Like 1X-Linked Receptor 1 Gene,Turmeric yellow,Curcumin,curcumin
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- MPTP
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CUR-L
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Curcumin low-dose (CUR-L) group received a combination of both treatments in which curcumin (40 mg/kg)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 12
- Group 1 sample size Number of subjects in the case (exposed) group
- 12
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
Signature 1
Source: Fig 5 and Text
Description: Analysis of species differences by LEfSe.
Abundance in Group 1: increased abundance in CUR-L
Revision editor(s): MyleeeA
Signature 2
Source: Fig 5 and Text
Description: Analysis of species differences by LEfSe.
Abundance in Group 1: decreased abundance in CUR-L
Revision editor(s): MyleeeA
