Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease/Experiment 7

From BugSigDB


Reviewed Marked as Reviewed by ChiomaBlessing on 2024-5-6

Curated date: 2024/04/09

Curator: MyleeeA

Revision editor(s): MyleeeA, ChiomaBlessing

Subjects

Location of subjects
South Korea
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Parkinson's disease IDIOPATHIC PARKINSON DIS,Idiopathic Parkinson Disease,Idiopathic Parkinson's Disease,IDIOPATHIC PARKINSONS DIS,Idiopathic PD,LEWY BODY PARKINSON DIS,Lewy Body Parkinson Disease,Lewy Body Parkinson's Disease,Paralysis agitans,paralysis agitans,PARKINSON DIS,PARKINSON DIS IDIOPATHIC,Parkinson disease,Parkinson Disease, Idiopathic,Parkinson syndrome,Parkinson's,Parkinson's disease,Parkinson's disease (disorder),Parkinson's disease NOS,Parkinson's disease NOS (disorder),Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinson's syndrome,Parkinsonian disorder,Parkinsonism, Primary,Parkinsons,PARKINSONS DIS,PARKINSONS DIS IDIOPATHIC,PARKINSONS DIS LEWY BODY,Parkinsons disease,Primary Parkinsonism,parkinson's disease
Group 0 name Corresponds to the control (unexposed) group for case-control studies
MPTP group
Group 1 name Corresponds to the case (exposed) group for case-control studies
MPTP+Acu group
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Mice treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) that received Acupuncture
Group 0 sample size Number of subjects in the control (unexposed) group
10
Group 1 sample size Number of subjects in the case (exposed) group
9
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
N/A

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Kruskall-Wallis
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
increased
Richness Number of species
increased

Signature 1

Reviewed Marked as Reviewed by ChiomaBlessing on 2024-5-6

Curated date: 2024/04/09

Curator: MyleeeA

Revision editor(s): MyleeeA, Mariposa, ChiomaBlessing

Source: Figure 5 and Supplementary Table S1

Description: Bacterial genera with significant differences in the gut microbiota of MPTP + Acu group VS MPTP group.

Abundance in Group 1: increased abundance in MPTP+Acu group

NCBI Quality ControlLinks
Acetatifactor
Acutalibacter
Alistipes
Alkalibacter
Anaeroplasma
Anaerosporobacter
Butyricimonas
Christensenella
Desulfitobacterium
Flavonifractor
Flintibacter
Gracilibacter
Kineothrix
Lachnoclostridium
Merdimmobilis
Oscillibacter
Pseudoflavonifractor

Revision editor(s): MyleeeA, Mariposa, ChiomaBlessing

Signature 2

Reviewed Marked as Reviewed by ChiomaBlessing on 2024-5-6

Curated date: 2024/04/09

Curator: MyleeeA

Revision editor(s): MyleeeA, ChiomaBlessing

Source: Figure 5 and Supplementary Table S1

Description: Bacterial genera with significant differences in the gut microbiota of MPTP + Acu group VS MPTP group.

Abundance in Group 1: decreased abundance in MPTP+Acu group

NCBI Quality ControlLinks
Aestuariispira
Bacteroides
Bifidobacterium
Desulfovibrio
Frisingicoccus
Holdemania
Marvinbryantia
Parabacteroides
Parasutterella
Phascolarctobacterium
Rhodospirillum
Sporobacter
Thomasclavelia
Turicibacter

Revision editor(s): MyleeeA, ChiomaBlessing