Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea/Experiment 2
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Diarrhea Diarrhea,Diarrhoea,Watery stool,diarrhea
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- post-cholecystectomy non-diarrhea (PCND)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- post-cholecystectomy diarrhea (PCD)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- This group included patients who experienced post-cholecystectomy diarrhea (PCD). These individuals had diarrhea as a clinical symptom following gallbladder removal.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 15
- Group 1 sample size Number of subjects in the case (exposed) group
- 16
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Signature 1
Source: Fig.2C
Description: Comparison of gut microbiota structure and abundance between the post-cholecystectomy non-diarrhea (PCND) and post-cholecystectomy diarrhea (PCD) groups. Linear discriminant analysis and effect size analysis show the taxa with the greatest differences in abundance between the PCND and PCD groups. Yellow bars: PCND group-enriched taxa; Green bars: PCD group-enriched taxa.
Abundance in Group 1: decreased abundance in post-cholecystectomy diarrhea (PCD)
Revision editor(s): Chinelsy, ChiomaBlessing
Signature 2
Source: Fig.2C
Description: Comparison of gut microbiota structure and abundance between the post-cholecystectomy non-diarrhea (PCND) and post-cholecystectomy diarrhea (PCD) groups. Linear discriminant analysis and effect size analysis show the taxa with the greatest differences in abundance between the PCND and PCD groups. Yellow bars: PCND group-enriched taxa; Green bars: PCD group-enriched taxa.
Abundance in Group 1: increased abundance in post-cholecystectomy diarrhea (PCD)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidales | ||
| Bacteroidia | ||
| Betaproteobacteria | ||
| Burkholderiales | ||
| Prevotella | ||
| Prevotellaceae | ||
| Sutterella |
Revision editor(s): Chinelsy, MyleeeA, ChiomaBlessing
